1583P Evaluation of immune checkpoint inhibitors rechallenge after immune-related adverse events in patients with cancer

Review: Immune-Related Adverse Events With Use of Checkpoint Inhibitors for Immunotherapy of Cancer.

A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors.

BACKGROUND There are limited data about the quality of immune-related adverse event (irAE) reporting in immune checkpoint inhibitor (ICI) clinical trial publications. METHODS A systematic search of citations from Medline, EMBASE and Cochrane databases identified prospective clinical trials involving ICIs in advanced solid tumors from 2003 to 2013. A 21-point quality score (QS) was adapted fro...

Adverse events after flu vaccination in patients with immune disorders.

In one case, an 89-year-old Chinese Indonesian male with eczema and allergic rhinitis was injected with the seasonal flu vaccine (not the H1N1 influenza vaccine) and a pneumococcus vaccine on 14 November 2009. His eczema was in remission at the time of injection. One week later he developed a skin rash that became progressively more severe, involving both upper limbs (Fig 1), both knees, and hi...

Immune checkpoint inhibitors in cancer therapy.

In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death protein 1 (PD-1) which have been shown to have potent immunomodulatory effects through their function as negative regu...

Renal Toxicity Related to Immune Checkpoint Inhibitors

As early as the 18th century, physicians noticed that some cancer patients went into remission after developing fevers from infections. This led to the idea that the immune system, which protects from infection, might also fight cancer. What is now known as “immunotherapy” is a treatment that targets the immune system to recognize and eradicate cancer cells. Modern immunotherapy has focused on ...